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Heavier individuals with more adipose tissue often benefit from doses at the higher end of the standard range (450-500mcg)

The authors identified the SREBP inhibitor betulin and showed that betulin treatment reduced the size and improved the stability of atherosclerotic plaques

Chronic high-dose vitamin B intake (generally in gram quantities daily over many months) has been linked to severe sensory neuropathy characterized by numbness, impaired proprioception, and paresthesia in a stocking-glove distribution